GeneTex

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United States (US)

APAF1 peptide

Cat. No. GTX22446

Application

 IP

Species

 Human
Package
500 μl ($179)
See all APAF1 products

APPLICATION

Application Note

Blocking peptide for rabbit polyconal antibody to APAF1(GTX22445).

Calculated MW

142 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, BSA

Preservative

0.1% Sodium azide

Storage

Store this product at 4ºC, DO NOT FREEZE. The product is stable for one year from the date of shipment.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Peptide mapping to the amino terminus of human Apaf-1.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

apoptotic peptidase activating factor 1 , APAF-1 , CED4

Cellular Localization

Cytoplasm

Background

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 179